Hydrogels made from gelatin and sodium alginate, structured with polyethylene glycol diepoxide, are used as a base for wound dressings. The conditions for preparation have been established and the optimal ratio of biopolymers and cross-linking agent in the hydrogel matrix has been determined. The antibacterial properties of the obtained hydrogels have been confirmed using bacterial test cultures of Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.
The results of the experiments show that the drugs are released from the gelatin-alginate hydrogel matrix, thus providing effective anesthesia for patients who need pain relief and prolonged antiseptic action to prevent infectious wound damage.
Gelatin and sodium alginate-based hydrogels have good potential as universal bases for wound treatment.